Center for Critical Care Nephrology


The Center for Critical Care Nephrology is an interdisciplinary research center with the goal of developing novel treatments and disruptive innovations to prevent, manage, and cure acute disorders of kidney function, as well as fluid and electrolyte balance, in critically ill patients. The Center’s diverse faculty and staff conduct basic, translational, and clinical research under these themes:

  • Acute kidney injury
  • Sepsis
  • Acute organ failure and organ support
  • Organ donor management
  • Biomarkers and blood purification

Primary Faculty

  • Joseph Carcillo, MD
  • David Emlet, PhD
  • Cassandra Formeck, MD, MS
  • Dana Fuhrman, DO
  • Hernando Gómez, MD
  • Raghavan Murugan, MD

Center Staff

  • Faye Cotton, Project Coordinator
  • Michele Elder, Operations Manager
  • Alicia Frank, Lab Technician
  • Karen Nieri, Executive Administrative Assistant
  • Priyanka Priyanka, MAS, Statistical Analyst

Visiting Scholars and Trainees

  • Robert Edgar, MA
  • Carlos Manrique, MD
  • Luca Molinari, MD
  • Muhammad Kumail Abbas, MD
  • Shoaib Wazir, MD
  • Rahul Bollam, MD

Affiliate Members

  • John Kellum, MD, MCCM

Phenotyping Renal Cases in Sepsis and Surgery for Early Acute Kidney Injury (PReCISE AKI)
This project studies whether biopsy findings predict patients at high risk for developing new or progressive CKD after an episode of acute kidney injury (AKI). It will relate biopsy findings to recovery status at various time points. Funding: NIDDK, UH3DK114861 (PI: Kellum)

The Role of Glycocalyx Shedding and Platelet Adhesion in Sepsis-induced Microvascular Dysfunction  
This study aims to investigate potential novel mechanisms involved in the development of sepsis-induced AKI. Funding: Vascular Medicine Institute University of Pittsburgh (PI: Gómez)

The Role of Energy Regulation in the Epithelial Cell Response to Sepsis and the Origin of Multiple Organ Dysfunction
To understand the role of energy regulation in the epithelial cell response to sepsis, and to determine the extent to which manipulation of energy regulatory pathways alters the course of sepsis-induced organ dysfunction. Funding: NIGMS, K08-GM117310 (PI: Gómez)

Biomarker Effectiveness Analysis in Contrast Nephropathy (BEACON)
The main objective of this proposal is to advance National Institute of Diabetes and Digestive Kidney Disease's mission of early detection, risk-stratification, and prognostication of contrast-induced AKI. It will provide new scientific knowledge on using biomarkers to monitor patients undergoing angiography and will have a high impact on clinical practice, physicians, and policy makers. Funding: NIDDK, R01DK106256 (PI: Murugan)

Protocolized Goal-directed Resuscitation of Septic Shock to Prevent AKI (ProGReSS AKI)
The goal of this project is to examine the natural history of AKI arising in patients with sepsis. Sepsis is found in more than 50% of critically ill patients with AKI. Funding: NIDDK, R01DK083961 (PI: Kellum)

Inflammation Phenotypes in Pediatric Sepsis Induced Multiple Organ Failure (PHENOMS)
We plan to use clinical information and samples already obtained from the PHENOMS study to help determine other causes of organ shutdown in children with sepsis. We aim to identify individually tailored treatments, precision medicine, for these causes to kill DNA viruses and reduce cytokine inflammation to further reduce death from sepsis organ shutdown in children. Funding: NIGMS, 2R01-GM108618 (PI: Carcillo)

The Center for Critical Care Nephrology also has a broad portfolio of industry-funded research collaborations.

For information on activities at the Center for Critical Care Nephrology or to inquire about collaborations and training opportunities, please contact mie1 [at] (Michele Elder), Operations Manager.



Interim Center Director

Jeremy M. Kahn, MD, MS
Professor of Critical Care Medicine and Health Policy & Management


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